Sepsis pediátrica: epidemiología, clínica y tratamiento

1. Carlton EF, Barbaro RP, Iwashyna TJ, Prescott HC. Cost of pediatric severe sepsis hospitalizations. JAMA Pediatr. 2019;173(10):986–987

2. Tan B, Wong JJ, Sultana R, et al. Global case-fatality rates in pediatric severe sepsis and septic shock: a systematic review and metaanalysis. JAMA Pediatr. 2019;173(4):352–362

3. Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study. Lancet. 2020;395(10219):200–211

4. Menon K, Schlapbach LJ, Akech S, et al; Pediatric Sepsis Definition Taskforce of the Society of Critical Care Medicine. Criteria for pediatric sepsis–a systematic review and meta-analysis by the Pediatric Sepsis Definition Taskforce. Crit Care Med. 2022;50(1):21–36

5. Boeddha NP, Schlapbach LJ, Driessen GJ, et al; EUCLIDS consortium. Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS). Crit Care. 2018;22(1):143

6. Weiss SL, Balamuth F, Hensley J, et al. The epidemiology of hospital death following pediatric severe sepsis: when, why, and how children with sepsis die. Pediatr Crit Care Med. 2017;18(9):823–830

7. Johnson KT, G€orges M, Murthy S. Characteristics and timing of mortality in children dying with infections in North American PICUs. Pediatr Crit Care Med. 2021;22(4):365–379

8. Schlapbach LJ, MacLaren G, Festa M, et al; Australian & New Zealand Intensive Care Society (ANZICS) Centre for Outcomes & Resource Evaluation (CORE) and Australian & New Zealand Intensive Care Society (ANZICS) Paediatric Study Group. Prediction of pediatric sepsis mortality within 1 h of intensive care admission. Intensive Care Med. 2017;43(8):1085–1096

9. Carlton EF, Donnelly JP, Hensley MK, Cornell TT, Prescott HC. New medical device acquisition during pediatric severe sepsis hospitalizations. Crit Care Med. 2020;48(5):725–731

10. Carlton EF, Kohne JG, Hensley MK, Prescott HC. Comparison of outpatient health care use before and after pediatric severe sepsis. JAMA Netw Open. 2020;3(9): e2015214

11. Carlton EF, Kohne JG, Shankar-Hari M, Prescott HC. Readmission diagnoses after pediatric severe sepsis hospitalization. Crit Care Med. 2019;47(4):583–590

12. Maddux AB, Zimmerman JJ, Banks RK, et al; Life After Lapse Sepsis Evaluation (LAPSE) Investigators. Health resource use in survivors of pediatric septic shock in the United States. Pediatr Crit Care Med. 2022;23(6): e277–e288

13. Zimmerman JJ, Banks R, Berg RA, et al; Life After Pediatric Sepsis Evaluation (LAPSE) Investigators. Trajectory of mortality and healthrelated quality of life morbidity following community-acquired pediatric septic shock. Crit Care Med. 2020;48(3):329–337

14. Dashefsky HS, Liu H, Hayes K, et al. Frequency of and risk factors associated with hospital readmission after sepsis. Pediatrics. 2023;152(1): e2022060819

15. Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL. Sepsis and septic shock. Nat Rev Dis Primers. 2016; 2:16045

16. Nakamori Y, Park EJ, Shimaoka M. Immune deregulation in sepsis and septic shock: reversing immune paralysis by targeting PD-1/ PD-L1 pathway. Front Immunol. 2021; 11:624279

17. Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801–810

18. Goldstein B, Giroir B, Randolph A; International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6(1):2–8

19. Schlapbach LJ. Time for Sepsis-3 in children? Pediatr Crit Care Med. 2017;18(8):805–806

20. Morin L, Hall M, de Souza D, et al; Pediatric Sepsis Definition Taskforce. The current and future state of pediatric sepsis definitions: an international survey. Pediatrics. 2022;149(6): e2021052565

21. Zhao C, Xin MY, Li J, et al. Comparing the precision of the pSOFA and SIRS scores in predicting sepsis-related deaths among hospitalized children: a multi-center retrospective cohort study. World J Emerg Med. 2022;13(4):259–265

22. Schlapbach LJ, Straney L, Bellomo R, MacLaren G, Pilcher D. Prognostic accuracy of age-adapted SOFA, SIRS, PELOD-2, and qSOFA for inhospital mortality among children with suspected infection admitted to the intensive care unit. Intensive Care Med. 2018;44(2):179–188

23. Balamuth F, Scott HF, Weiss SL, et al; Pediatric Emergency Care Applied Research Network (PECARN) PED Screen and PECARN Registry Study Groups. Validation of the Pediatric Sequential Organ Failure Assessment Score and Evaluation of Third International Consensus Definitions for Sepsis and Septic Shock Definitions in the Pediatric Emergency Department. JAMA Pediatr. 2022;176(7):672–678

24. Bembea MM, Agus M, Akcan-Arikan A, et al. Pediatric Organ Dysfunction Information Update Mandate (PODIUM) contemporary organ dysfunction criteria: executive summary. Pediatrics. 2022; 149(1 Suppl 1): S1–S12

25. Leclerc F, Duhamel A, Deken V, Grandbastien B, Leteurtre S; Groupe Francophone de R[1]eanimation et Urgences P[1]ediatriques (GFRUP). Can the pediatric logistic organ dysfunction-2 score on day 1 be used in clinical criteria for sepsis in children? Pediatr Crit Care Med. 2017;18(8):758–763

26. Leteurtre S, Duhamel A, Salleron J, Grandbastien B, Lacroix J, Leclerc F; Groupe Francophone de R[1]eanimation et d’Urgences P[1]ediatriques (GFRUP). PELOD-2: an update of the PEdiatric logistic organ dysfunction score. Crit Care Med. 2013;41(7):1761–1773

27. Matics TJ, Sanchez-Pinto LN. Adaptation and validation of a pediatric sequential organ failure assessment score and evaluation of the Sepsis-3 definitions in critically ill children. JAMA Pediatr. 2017;171(10): e172352

28. Sanchez-Pinto LN, Bembea MM, Farris RW, et al; Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative. Patterns of organ dysfunction in critically ill children based on PODIUM criteria. Pediatrics. 2022;149(1 Suppl 1): S103–S110

29. Schlapbach LJ, Weiss SL, Bembea MM, et al; Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative. Scoring systems for organ dysfunction and multiple organ dysfunction: the PODIUM Consensus Conference. Pediatrics. 2022; 149(1 Suppl 1): S23–S31

30. Carrol ED, Ranjit S, Menon K, et al; Society of Critical Care Medicine’s Pediatric Sepsis Definition Taskforce. Operationalizing appropriate sepsis definitions in children worldwide: considerations for the pediatric sepsis definition taskforce. Pediatr Crit Care Med. 2023;24(6): e263–e271

31. Pierrakos C, Velissaris D, Bisdorff M, Marshall JC, Vincent JL. Biomarkers of sepsis: time for a reappraisal. Crit Care. 2020;24(1):287

32. Scott HF, Brou L, Deakyne SJ, Kempe A, Fairclough DL, Bajaj L. Association between early lactate levels and 30-day mortality in clinically suspected sepsis in children. JAMA Pediatr. 2017;171(3):249–255

33. Weiss SL, Peters MJ, Alhazzani W, et al. Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Pediatr Crit Care Med. 2020;21(2): e52–e106

34. Weiss SL, Peters MJ, Alhazzani W, et al. Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Med. 2020;46(suppl 1):10–67

35. Downes KJ, Fitzgerald JC, Weiss SL. Utility of procalcitonin as a biomarker for sepsis in children. J Clin Microbiol. 2020;58(7): e01851-19

36. Byler S, Baker A, Freiman E, Herigon JC, Eisenberg MA. Utility of specific laboratory biomarkers to predict severe sepsis in pediatric patients with SIRS. Am J Emerg Med. 2021; 50:778–783

37. Nour Z, El-Hamamsy K, Ehsan I, et al. MicroRNAs as potential diagnostic new biomarkers in diagnosis of sepsis in pediatric patients. Rep Biochem Mol Biol. 2022;11(2):327–335

38. Wong HR, Cvijanovich NZ, Anas N, et al. Improved risk stratification in pediatric septic shock using both protein and mRNA biomarkers. PERSEVERE-XP. Am J Respir Crit Care Med. 2017;196(4):494–501

39. Pierce RW, Giuliano JS, Whitney JE, Ouellette Y; Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative. Endothelial dysfunction criteria in critically ill children: the PODIUM Consensus Conference. Pediatrics. 2022;149(1 Suppl 1): S97–S102

40. Fern[1]andez-Sarmiento J, Molina CF, Salazar-Pelaez LM, et al. Biomarkers of glycocalyx injury and endothelial activation are associated with clinical outcomes in patients with sepsis: a systematic review and meta-analysis. J Intensive Care Med. 2023;38(1):95–105

41. Tyszko M, Lema[1]nska-Perek A, [1]Smiechowicz J, et al. Citrulline, intestinal fatty acid-binding protein and the acute gastrointestinal injury score as predictors of gastrointestinal failure in patients with sepsis and septic shock. Nutrients. 2023;15(9):2100

42. Whitney JE, Zhang B, Koterba N, et al. Systemic endothelial activation is associated with early acute respiratory distress syndrome in children with extrapulmonary sepsis. Crit Care Med. 2020;48(3):344–352

43. Beliz[1]ario JE, Faintuch J, Malpartida MG. Breath biopsy and discovery of exclusive volatile organic compounds for diagnosis of infectious diseases. Front Cell Infect Microbiol. 2021; 10:564194

44. Balamuth F, Alpern ER, Abbadessa MK, et al. Improving recognition of pediatric severe sepsis in the emergency department: contributions of a vital sign-based electronic alert and bedside clinician identification. Ann Emerg Med. 2017;70(6):759–768.e2

45. Eisenberg M, Madden K, Christianson JR, Melendez E, Harper MB. Performance of an automated screening algorithm for early detection of pediatric severe sepsis. Pediatr Crit Care Med. 2019; 20(12): e516–e523

46. Lloyd JK, Ahrens EA, Clark D, Dachenhaus T, Nuss KE. Automating a manual sepsis screening tool in a pediatric emergency department. Appl Clin Inform. 2018;9(4):803–808

47. Eisenberg MA, Balamuth F. Pediatric sepsis screening in US hospitals. Pediatr Res. 2022;91(2):351–358

48. Fleuren LM, Klausch TLT, Zwager CL, et al. Machine learning for the prediction of sepsis: a systematic review and meta-analysis of diagnostic test accuracy. Intensive Care Med. 2020;46(3):383–400

49. Kamaleswaran R, Akbilgic O, Hallman MA, West AN, Davis RL, Shah SH. Applying artificial intelligence to identify physiomarkers predicting severe sepsis in the PICU. Pediatr Crit Care Med. 2018;19(10): e495–e503