1. Hall IC, O’Toole E. Intestinal flora in new-born infants: with a description of a new pathogenic anaerobe, bacillus difficilis. Am J Dis Child. 1935;49(2):390–402
2. Guh AY, Mu Y, Winston LG, et al; Emerging Infections Program Clostridioides difficile Infection Working Group. Trends in U.S. burden of Clostridioides difficile infection and outcomes. N Engl J Med. 2020;382(14):1320–1330
3. Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States, 2019. Available at: www.cdc.gov/DrugResistance/Biggest-Threats.html. Accessed April 7, 2023
4. Miranda-Katz M, Parmar D, Dang R, Alabaster A, Greenhow TL. Epidemiology and risk factors for community associated Clostridioides difficile in children. J Pediatr. 2020; 221:99–106
5. Lessa FC, Mu Y, Bamberg WM, et al. Burden of Clostridium difficile infection in the United States. N Engl J Med. 2015;372(9):825–834
6. Zilberberg MD, Tillotson GS, McDonald C. Clostridium difficile infections among hospitalized children, United States, 1997-2006. Emerg Infect Dis. 2010;16(4):604–609
7. Edwards PT, Thurm CW, Hall M, et al. Clostridioides difficile infection in hospitalized pediatric patients: comparisons of epidemiology, testing, and treatment from 2013 to 2019. J Pediatr. 2023; 252:111–116.e1
8. Silva A, Du T, Choi KB, et al; CNISP C. difficile working group. Epidemiology of primary and recurrent healthcare-associated and community-associated pediatric Clostridioides difficile infection in Canada, 2015-2020. J Pediatric Infect Dis Soc. 2023;12(4):222–225
9. Mehrotra P, Jang J, Gidengil C, Sandora TJ. Attributable cost of Clostridium difficile infection in pediatric patients. Infect Control Hosp Epidemiol. 2017;38(12):1472–1477
10. Lurienne L, Bandinelli PA, Galvain T, Coursel CA, Oneto C, Feuerstadt P. Perception of quality of life in people experiencing or having experienced a Clostridioides difficile infection: a US population survey. J Patient Rep Outcomes. 2020;4(1):14
11. McDonald LC, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018;66(7): e1–e48
12. Centers for Disease Control and Prevention. Healthcare-Associated Infections - Community Interface (HAIC) Clostridioides difficile infections. Available at: https://www.cdc.gov/hai/eip/haicviz. html. Accessed December 8, 2022
13. Pant C, Deshpande A, Gilroy R, Olyaee M, Donskey CJ. Rising incidence of Clostridium difficile related discharges among hospitalized children in the United States. Infect Control Hosp Epidemiol.
2016;37(1):104–106
14. Centers for Disease Control and Prevention. COVID-19: U.S. impact on antimicrobial resistance, special report 2022. Available at: https://www.cdc.gov/drugresistance/pdf/covid19-impact-report-508.pdf. Accessed May 23, 2023
15. Lees EA, Carrol ED, Ellaby NAF, et al. Characterization of circulating Clostridium difficile strains, host response and intestinal microbiome in hospitalized children with diarrhea. Pediatr Infect Dis J. 2020;39(3):221–228
16. Shuai H, Bian Q, Luo Y, et al. Molecular characteristics of Clostridium difficile in children with acute gastroenteritis from Zhejiang. BMC Infect Dis. 2020;20(1):343
17. Perumalsamy S, Lim SC, Riley TV. Clostridioides (Clostridium) difficile isolated from paediatric patients in Western Australia 2019-2020. Pathology. 2022;54(4):460–465
18. Al-Rawahi GN, Al-Najjar A, McDonald R, et al. Pediatric oncology
and stem cell transplant patients with healthcare-associated Clostridium difficile infection were already colonized on admission. Pediatr Blood Cancer. 2019;66(5): e27604
19. Tougas SR, Lodha N, Vandermeer B, et al. Prevalence of detection of Clostridioides difficile among asymptomatic children: a systematic review and meta-analysis. JAMA Pediatr. 2021;175(10): e212328
20. Pichler K, Bausenhardt B, Huhulescu S, et al. Impact and time course of Clostridium difficile colonization in very low birth weight infants. Neonatology. 2018;114(2):149–154
21. Ferraris L, Couturier J, Eckert C, et al. Carriage and colonization of C. difficile in preterm neonates: a longitudinal prospective study. PLoS One. 2019;14(2): e0212568
22. Brennhofer SA, Rogawski McQuade ET, Liu J, Guerrant RL, Platts Mills JA, Warren CA. Clostridioides difficile colonization among very young children in resource-limited settings. Clin Microbiol Infect. 2022;28(7):996–1002
23. Xie X, Xiang B, Wu Y, Zhao Y, Wang Q, Jiang X. Infant progressive colonic stenosis caused by antibiotic-related Clostridium difficile colitis - a case report and literature review. BMC Pediatr. 2018; 18(1):320
24. Eglow R, Pothoulakis C, Itzkowitz S, et al. Diminished Clostridium difficile toxin A sensitivity in newborn rabbit ileum is associated with decreased toxin A receptor. J Clin Invest. 1992;90(3):822–829
25. Kociolek LK, Espinosa RO, Gerding DN, et al. Natural Clostridioides difficile toxin immunization in colonized infants. Clin Infect Dis. 2020;70(10):2095–2102
26. Hourigan SK, Sears CL, Oliva-Hemker M. Clostridium difficile infection in pediatric inflammatory bowel disease. Inflamm Bowel Dis. 2016;22(4):1020–1025
27. Theunissen C, Knoop C, Nonhoff C, et al. Clostridium difficile colitis in cystic fibrosis patients with and without lung transplantation. Transpl Infect Dis. 2008;10(4):240–244
28. Dominguez SR, Dolan SA, West K, et al. High colonization rate and prolonged shedding of Clostridium difficile in pediatric oncology patients. Clin Infect Dis. 2014;59(3):401–403
29. Ochfeld E, Balmert LC, Patel SJ, Muller WJ, Kociolek LK. Risk factors for Clostridioides (Clostridium) difficile infection following solid organ transplantation in children. Transpl Infect Dis. 2019;21(5): e13149
30. Duclaux-Loras R, Berthiller J, Ferroni A, et al. Clostridium difficile: a frequent infection in children after intestinal transplantation. Transplantation. 2020;104(1):197–200
31. Leibowitz J, Soma V, Rosen L, Ginocchio C, Rubin L. Similar proportions of stool specimens from hospitalized children with and without diarrhea test positive for Clostridium difficile. Pediatr Infect Dis J. 2014;34(3):261–266
32. Anjewierden S, Han Z, Foster CB, Pant C, Deshpande A. Risk factors for Clostridium difficile infection in pediatric inpatients: a meta-analysis and systematic review. Infect Control Hosp Epidemiol. 2019;40(4):420–426
33. Adams DJ, Eberly MD, Rajnik M, Nylund CM. Risk factors for community-associated Clostridium difficile infection in children. J Pediatr. 2017; 186:105–109
34. Weng MK, Adkins SH, Bamberg W, et al. Risk factors for community-associated Clostridioides difficile infection in young children. Epidemiol Infect. 2019;147: e172
35. Ramirez J, Guarner F, Bustos Fernandez L, Maruy A, Sdepanian VL, Cohen H. Antibiotics as major disruptors of gut microbiota. Front Cell Infect Microbiol. 2020; 10:572912
36. Smith AB, Jenior ML, Keenan O, et al. Enterococci enhance Clostridioides difficile pathogenesis. Nature. 2022;611(7937):780–786
37. Dang R, Alabaster A, Miranda-Katz M, Parmar D, Greenhow TL. Impact of antecedent antibiotic usage on community-associated Clostridioides difficile infection in Pediatrics. Pediatr Infect Dis J. 2021;40(5):426–428
38. Kociolek LK, Gerding DN, Espinosa RO, Patel SJ, Shulman ST, Ozer EA. Clostridium difficile Whole Genome Sequencing Reveals Limited Transmission Among Symptomatic Children: A Single-Center Analysis. Clin Infect Dis. 2018;67(2):229–234
39. Chitnis AS, Holzbauer SM, Belflower RM, et al. Epidemiology of community-associated Clostridium difficile infection, 2009 through 2011. JAMA Intern Med. 2013;173(14):1359–1367
40. Wilcox MH, Mooney L, Bendall R, Settle CD, Fawley WN. A case-control
study of community-associated Clostridium difficile infection. J Antimicrob Chemother. 2008;62(2):388–396
41. Rabold D, Espelage W, Abu Sin M, et al. The zoonotic potential of Clostridium difficile from small companion animals and their owners. PLoS One. 2018;13(2): e0193411
42. Kociolek LK, Patel SJ, Shulman ST, Gerding DN. Molecular epidemiology of Clostridium difficile infections in children: a retrospective cohort study. Infect Control Hosp Epidemiol. 2015;36(4):445–451
43. Perumalsamy S, Riley TV. Molecular epidemiology of Clostridioides difficile infections in children. J Pediatric Infect Dis Soc. 2021; 10(Supplement_3): S34–S40
44. Loftus KV, Wilson PM. A curiously rare case of septic shock from Clostridium difficile colitis. Pediatr Emerg Care. 2017;33(8):576–578
45. Wendt JM, Cohen JA, Mu Y, et al. Clostridium difficile infection among children across diverse US geographic locations. Pediatrics. 2014;133(4):651–658
46. Nicholson MR, Crews JD, Starke JR, Jiang ZD, DuPont H, Edwards K. Recurrent Clostridium difficile infection in children: patient risk factors and markers of intestinal inflammation. Pediatr Infect Dis J. 2017;36(4):379–383
47. Orenstein R, Patron RL, Seville MT. Why does Clostridium difficile infection recur? J Am Osteopath Assoc. 2019;119(5):322–326
48. Chang JY, Antonopoulos DA, Kalra A, et al. Decreased diversity of the fecal microbiome in recurrent Clostridium difficile-associated diarrhea. J Infect Dis. 2008;197(3):435–438
49. Schwab EM, Wilkes J, Korgenski K, Hersh AL, Pavia AT, Stevens VW. Risk factors for recurrent Clostridium difficile infection in pediatric inpatients. Hosp Pediatr. 2016;6(6):339–344
50. Ruan W, Kellermayer R. Alternative diagnoses in pediatric fecal microbiota transplant referral patients. J Pediatr Gastroenterol Nutr. 2021;72(5):693–696
51. Sandora TJ, Williams DN, Daugherty K, et al. Stool toxin concentration does not distinguish Clostridioides difficile infection from colonization in children less than 3 years of age. J Pediatric Infect Dis Soc. 2022;11(10):454–458
52. Parnell JM, Fazili I, Bloch SC, et al. Two-step testing for Clostridioides difficile is inadequate in differentiating infection from colonization in children. J Pediatr Gastroenterol Nutr. 2021;72(3):378–383
53. Pahud BA, Hassan F, Harrison CJ, et al. Detection of Clostridioides difficile by real-time PCR in young children does not predict disease. Hosp Pediatr. 2020;10(7):555–562
54. Sethi AK, Al-Nassir WN, Nerandzic MM, Bobulsky GS, Donskey CJ. Persistence of skin contamination and environmental shedding of Clostridium difficile during and after treatment of C. difficile infection. Infect Control Hosp Epidemiol. 2010;31(1):21–27
55. Kelly CR, Fischer M, Allegretti JR, et al. ACG clinical guidelines: prevention, diagnosis, and treatment of Clostridioides difficile infections. Am J Gastroenterol. 2021;116(6):1124–1147
56. Coffin SE, Abanyie F, Bryant K, et al; CDC Prevention Epicenters Program. Pediatric research priorities in healthcare-associated infections and antimicrobial stewardship. Infect Control Hosp Epidemiol. 2021;42(5):519–522
57. Kociolek LK, Kutty PK, Polgreen PM, Beekmann SE. Healthcare provider diagnostic testing practices for identification of Clostridioides (Clostridium) difficile in children: An Emerging Infections Network survey. Infect Control Hosp Epidemiol. 2019;40(3):276–280
58. Tran NN, Mills JP, Zimmerman C, et al. Incorporating preauthorization into antimicrobial stewardship pharmacist workflow reduces Clostridioides difficile and gastrointestinal panel testing. Infect Control Hosp Epidemiol. 2020;41(10):1136–1141
59. Cotter JM, Thomas J, Birkholz M, et al. Impact of multiplex testing on the identification of pediatric Clostridiodes difficile. J Pediatr. 2020; 218:157–165.e3
60. Zhou P, Zhou N, Shao L, et al. Diagnosis of Clostridium difficile infection using an UPLC-MS based metabolomics method. Metabolomics. 2018;14(8):102
61. Galvez JAV, Pollock NR, Alonso CD, et al. Stool interleukin-1b differentiates Clostridioides difficile infection from asymptomatic carriage and non-C.difficile infection diarrhea. Clin Infect Dis. 2023;76(3): e1467–e1475
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